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On the Treatment of Rapid Eye Movement Narcolepsy
Christian Guilleminault, MD;
Mary Carskadon;
William C. Dement, MD, PhD
Arch Neurol. 1974;30(1):90-93.
Abstract
Fifty patients were diagnosed as having rapid eye movement (REM) narcolepsy by means of polygraphic recordings. The effectiveness of amphetamine and tricyclic antidepressant drugs on the classical symptoms of REM narcolepsy were considered. Side effects developed with each of these medications. Imipramine hydrochloride and clomipramine hydrochloride appear to be effective for cataplexy, sleep paralysis and hypnagogic hallucinations, but there is no effective and harmless treatment for daytime sleep attacks.
Author Affiliations
Stanford, Calif
From the Sleep Disorders Clinic and Laboratory, Stanford University School of Medicine, Stanford, Calif.
Footnotes
Accepted for publication Aug 9, 1973.
Reprint requests to Sleep Disorders Clinic and Laboratory, Stanford University School of Medicine, Stanford, CA 94305 (Dr. Guilleminault).
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