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Lalit M. Ambani, MD; Melvin H. Van Woert, MD; Malcolm B. Bowers, Jr., MD

Arch Neurol. 1973;29(6):444-446.

Abstract
The effect of an intravenous injection of physostigmine salicylate (1 mg) on the extrapyramidal side effects of phenothiazine therapy was investigated in ten psychiatric patients. Six of the ten patients who had developed minimal rigidity or tremor or both during phenothiazine therapy exhibited a worsening of these neurological signs after the physostigmine injection. It is concluded that cholinergic hyperactivity or hypersensitivity or both occur in phenothiazine-induced Parkinsonism as well as idiopathic Parkinson disease.

Author Affiliations
New Haven, Conn

From the departments of internal medicine, pharmacology (Drs. Ambani and Van Woert), and psychiatry (Dr. Bowers), Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication July 18,1973.

Reprint requests to Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510 (Dr. Ambani).

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ABSTRACT