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A Serum Isozyme Study in Muscular DystrophyParticular Reference to Creatine Kinase, Aspartate Aminotransferase, and Lactic Acid Dehydrogenase Isozymes
Hannu Somer, MD;
Märta Donner, MD;
Juhani Murros, MD;
Aarne Konttinen, MD
Arch Neurol. 1973;29(5):343-345.
Abstract
Creatine kinase MB isozyme was found in the serum of 29 (91%) patients with progressive or congenital muscular dystrophy. The magnitude of its elevation exceeded that of other enzymes or isozymes studied. Mitochondrial aspartate aminotransferase (mAST) was detected in the serum of only seven patients (24%), all at an early stage of the disease, and it constituted without exception 5% or less of the total AST activity. Elevations of lactic acid dehydrogenase (LDH) activity were mainly due to increases of LDH1-3 isozyme activity.
Author Affiliations
Helsinki
From the Wihuri Research Institute (Drs. Somer, Murros, and Konttinen), and the departments of pediatrics (Dr. Donner) and neurology (Dr. Somer), University Central Hospital, Helsinki.
Footnotes
Accepted for publication May 16, 1973.
Reprint requests to Wihuri Research Institute, It Kaivop tie 23 B, 00140 Helsinki 14, Finland (Dr. Somer).
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