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Virus Isolation From Brain Biopsy in Seven Patients and Results of Therapy

Felix A. Sarubbi, Jr., MD; P. Frederick Sparling, MD; W. Paul Glezen, MD

Arch Neurol. 1973;29(4):268-273.

Abstract
Recent experience suggests that Herpesvirus hominis is the commonest cause of sporadic necrotizing encephalitis in man. We documented H hominis encephalitis in seven patients aged 8 months to 70 years. Five of these seven patients were admitted to our hospital in a 13-month period of time. Four patients were treated with idoxuridine, and three of these died. One patient who received a full course of idoxuridine yielded H hominis from postmortem brain samples in titers approximately equal to those found in the pretreatment brain biopsy specimen. The lone survivor was left with significant neurological deficits. Two patients were treated with cytarabine and, although they remain alive, both are hospitalized in chronic care institutions. The duration and severity of illness manifest by these patients may have adversely affected the outcome of therapy.

Author Affiliations
Chapel Hill, NC

From the departments of medicine and bacteriology (Drs. Sarubbi and Sparling), and pediatrics (Dr. Glezen), University of North Carolina School of Medicine, Chapel Hill, NC.

Footnotes
Accepted for publication May 31, 1973.

Reprint requests to departments of medicine and bacteriology, University of North Carolina School of Medicine, Chapel Hill, NC 27514 (Dr. Sarubbi).

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