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Relation to Norepinephrine Release From Brain Slices

Jonathan H. Pincus, MD; SooHee Lee, MS

Arch Neurol. 1973;29(4):239-244.

Abstract
Diphenylhydantoin and calcium act antagonistically with respect to stimulus-coupled dl-norepinephrine-³H (NE³H) release from rat brain slices. Diphenylhydantoin also reduced calcium Ca 45 (⁴⁵Ca) uptake into brain tissue. Procaine had a similar effect on NE³H release and ⁴⁵Ca uptake; (hydroxyphenyl) phenylhydantoin, phenobarbital, and tetrodotoxin had no effect on either. Ouabain increased NE³H release and ⁴⁵Ca uptake. The NE³H release from brain slices was sensitive to other circumstances that affect calcium movement: It was increased in low sodium media and decreased by high magnesium concentrations.

These results are compatible with the hypothesis that diphenylhydantoin acts like a local anesthetic and primarily limits membrane permeability to calcium.

Author Affiliations
New Haven, Conn

From the Department of Neurology, Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication May 9, 1973.

Read in part before the American Academy of Neurology, St. Louis, April 29, 1972.

Reprint requests to Department of Neurology, Yale University School of Medicine, New Haven, CT 06510 (Dr. Pincus).

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