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Adenosine 3', 5'-Monophosphate in Cerebrospinal FluidEffect of Drugs and Neurologic Disease
Hinrich Cramer, MD;
Larry K. Y. Ng, MD;
Thomas N. Chase, MD
Arch Neurol. 1973;29(3):197-199.
Abstract
Adenosine 3',5'-monophosphate (cyclic AMP) was measured in lumbar spinal fluid of 41 patients with peripheral or central nervous system (CNS) disease. Cyclic AMP levels appeared unrelated to age, sex, or time of day that samples were obtained. Levels in patients with Parkinson's disease did not differ significantly from those in patients with familial or acquired dyskinesias, spinocerebellar disorders, or from those in patients free of CNS disease. Neither acute nor chronic administration of levodopa altered cyclic AMP concentrations. In contrast, probenecid caused a substantial rise in levels of this nucleotide. Results suggest that cyclic AMP efflux from the spinal fluid compartment may be mediated by a probenecid-sensitive transport system and that use of probenecid may provide a means for studying drug or disease effects on the central turnover of cyclic AMP in man.
Author Affiliations
Bethesda, Md
From the Neurology Unit, National Institute of Mental Health, Bethesda, Md. Dr. Cramer is now with the Department of Neurology, University of Freiburg, Freiburg, Germany.
Footnotes
Accepted for publication May 16, 1973.
Reprint requests to Neurology Unit, National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, MD 20014 (Dr. Chase).
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