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Pacifico V. de Jesus, Jr., MD; David E. Pleasure, MD

Arch Neurol. 1973;29(3):180-182.

Abstract
Rats fed hexachlorophene developed polyneuropathy that was related to dose and time of exposure. Rats fed larger doses had hind-limb wasting and weakness. The motor conduction velocities of sciatic nerves were decreased. The nerves were edematous, and less myelin could be recovered from them. Within a week after discontinuation of hexachlorophene feeding, neuromuscular dysfunction cleared and the nerve conduction velocities returned to normal.

Author Affiliations
Philadelphia

From the Department of Neurology, University of Pennsylvania, School of Medicine, and Philadelphia General Hospital, Philadelphia.

Footnotes
Accepted for publication May 16, 1973.

Reprint requests to Hospital of the University of Pennsylvania, Philadelphia 19104 (Dr. de Jesus).

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