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Immunologic Mechanisms in Experimental Encephalomyelitis in Nonhuman Primates
Peter O. Behan, MD;
Marian W. Kies, PhD;
Robert P. Lisak, MD;
William Sheremata, MD;
Jacques B. Lamarche
Arch Neurol. 1973;29(1):4-9.
Abstract
Experimental allergic encephalomyelitis was induced in large rhesus monkeys by immunizing them with homologous and heterologous myelin basic proteins in different adjuvants. Two clinically and pathologically different types of disease, ordinary and hyperacute, were produced. In both types cell-mediated hypersensitivity was demonstrated to a variety of myelin basic proteins from different species by in vivo and in vitro techniques. Humoral antibody to homologous myelin basic protein could only be found in the fulminant hyperacute form.
Author Affiliations
Boston; Bethesda, Md; Philadelphia; Montreal; Quebec
From the departments of neurology and neuropathology, Boston University School of Medicine and the Boston Veterans Administration Hospital; and the Section on Myelin Chemistry, Laboratory on Cerebral Metabolism, National Institute of Mental Health, Bethesda, Md.
Footnotes
Accepted for publication Feb 21, 1973.
Read in part before the annual meeting of the American Association of Neuropathologists, New Haven, Conn, June 22, 1969.
Reprint requests to Veterans Administration Hospital, Department of Neurology, 150 S Huntington Ave, Boston 02130 (Dr. Behan).
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