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Claude G. Wasterlain, MD; Fred Plum, MD

Arch Neurol. 1973;29(1):38-45.

Abstract
Seventy-four immature rats received one supramaximal electroconvulsive seizure per day for ten days. Compared to paired control littermates, animals subjected to seizures between days 2 and 11 of postnatal life had a reduction in brain weight (—14%, P<.01) and brain cell number (—15%, P<.01). Rats convulsed between days 9 and 18 of life underwent a reduction in brain weight (—8%, P<.01), brain protein, and brain RNA without fall in brain DNA, suggesting a reduction of cell size without change in cell number. The largely postmitotic brain of animals shocked later in life (days 19 to 28) showed no change in brain weight, cell number, or cell size. No focal histological abnormalities were found in any group. These data suggest that the immature rat brain is vulnerable to seizures that leave the brain of older animals undamaged.

Author Affiliations
New York

From the Department of Neurology, Cornell University Medical College, New York.

Footnotes
Accepted for publication April 5, 1973.

Read before the American Neurological Association, Chicago, June 13, 1972.

Reprint requests to Department of Neurology, Cornell University Medical College, 1300 York Ave, New York 10021 (Dr. Wasterlain).

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