Vulnerability of Developing Rat Brain to Electroconvulsive Seizures

doi:10.1001/archneur.1973.00490250056006

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Vol. 29 No. 1, July 1973

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Vulnerability of Developing Rat Brain to Electroconvulsive Seizures

Claude G. Wasterlain, MD; Fred Plum, MD

Arch Neurol. 1973;29(1):38-45.

Abstract

Seventy-four immature rats received one supramaximal electroconvulsiveseizure per day for ten days. Compared to paired control littermates,animals subjected to seizures between days 2 and 11 of postnatallife had a reduction in brain weight (—14%, P<.01)and brain cell number (—15%, P<.01). Rats convulsedbetween days 9 and 18 of life underwent a reduction in brainweight (—8%, P<.01), brain protein, and brain RNA withoutfall in brain DNA, suggesting a reduction of cell size withoutchange in cell number. The largely postmitotic brain of animalsshocked later in life (days 19 to 28) showed no change in brainweight, cell number, or cell size. No focal histological abnormalitieswere found in any group. These data suggest that the immaturerat brain is vulnerable to seizures that leave the brain ofolder animals undamaged.

Author Affiliations

New York

From the Department of Neurology, Cornell University Medical College, New York.

Footnotes

Accepted for publication April 5, 1973.

Read before the American Neurological Association, Chicago,June 13, 1972.

Reprint requests to Department of Neurology, Cornell UniversityMedical College, 1300 York Ave, New York 10021 (Dr. Wasterlain).

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