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Barrier Properties
Adolf Weindl, MD;
Robert J. Joynt, MD, PhD
Arch Neurol. 1973;29(1):16-22.
Abstract
The capillary loops of the subcommissural organ of the rabbit consist of nonfenestrated endothelial cells interconnected by circular tight junctions. The endothelial wall is surrounded by a perivascular connective tissue sheath. Horseradish peroxidase (HRP), after intravenous injection, cannot leave the capillary lumen because of the interendothelial tight junctions. After intraventricular injection, HRP enters the intercellular clefts from the ventricles through apical gap junctions and travels toward the perivascular sheath. After crossing the extracellular compartment of the perivascular space and the subendothelial basal lamina, HRP reaches the distal part of the interendothelial cleft but never the luminal side of the tight junction. The lack of transport of this protein molecule does not favor the concept of basal secretion.
Author Affiliations
Rochester, NY
From the Department of Neurology, University of Rochester, Rochester, NY.
Footnotes
Accepted for publication Jan 10, 1973.
Reprint requests to the Department of Neurology, University of Rochester, 260 Crittenden Blvd, Rochester, NY 14642 (Dr. Joynt).
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