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Berry Campbell, PhD; Philip J. Vogel, MD; Edison Fisher, MD; Robert Lorenz, MD

Arch Neurol. 1973;29(1):10-15.

Abstract
Sixty-four subjects served in a doubleblind trial to test the efficacy of desensitization to human myelin basic protein (BP) as a therapy in multiple sclerosis. A difference appeared in the self-evaluation of the patients of the two groups, the experimentals appearing statistically better at periods late in the trial. Some patients were able to tell the BP from the placebo by a feeling of well-being, which the protein induced, others by improvement of bladder control or feeling of fatigue. No adverse reactions were encountered. The approach appears valid and should be pursued further with larger doses of BP or with the synthetic peptide fragments.

Author Affiliations
Los Angeles

From the departments of neurosurgery (Drs. Campbell and Vogel) and neurology (Drs. Fisher and Lorenz), White Memorial Medical Center, Los Angeles. Dr. Campbell is now with the University of California, College of Medicine, Irvine, Calif.

Footnotes
Accepted for publication March 27, 1973.

Reprint requests to Department of Physiology, University of California, College of Medicine, Irvine, CA 92664 (Dr. Campbell).

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