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Rapid Identification and Subsequent Isolation

Leslie P. Weiner, MD; Opendra Narayan, DVM, PhD; John B. Penney, Jr.; Robert M. Herndon, MD; Earl R. Feringa, MD; Wallace W. Tourtellotte, MD; Richard T. Johnson, MD

Arch Neurol. 1973;29(1):1-3.

Abstract
A papovavirus of the JC type was identified in the brain of a patient dying of progressive multifocal leukoencephalopathy (PML) complicating chronic lymphocytic leukemia. Rapid antigenic typing of the virus was carried out by fluorescent antibody staining of the brain and by electron microscopic agglutination of virus particles extracted directly from the brain. Subsequently, the virus was isolated from brain tissue in primary cell cultures of human fetal brain. This second association of JC virus with PML confirms that at least two antigenically distinct viruses may cause PML and demonstrates that methods are now available for the rapid identification of the papovaviruses that may be related to the disease.

Author Affiliations
Baltimore; Ann Arbor; Los Angeles; Baltimore

From the departments of neurology (Drs. Weiner, Narayan, Herndon, and Johnson) and laboratory animal medicine (Dr. Narayan), Johns Hopkins University School of Medicine, Baltimore; the departments of neurology and pathology (Dr. Feringa), Veterans Administration and University of Michigan, Ann Arbor; and the Department of Neurology (Dr. Tourtellotte), VA Wadsworth Hospital Center and UCLA, Los Angeles. Mr. Penny, a medical student at Johns Hopkins, is a Henry Strong Denison Scholar for 1972-1973.

Footnotes
Accepted for publication Feb 14, 1973.

Reprint requests to Department of Neurology, Johns Hopkins University School of Medicine, Traylor Bldg 709, Baltimore 21205 (Dr. Weiner).

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