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Alan K. Percy, MD; Ursula M. McCormick; Michael M. Kaback, MD; Robert M. Herndon, MD

Arch Neurol. 1973;28(6):417-419.

Abstract
G_M1 and G_M2 gangliosidosis were detected in utero by amniocentesis with culture of the amniocytes followed by enzyme assay. Diagnosis was followed by saline-induced abortion. Electron microscopic examination of the spinal cords of aborted midterm fetuses revealed membranous cytoplasmic bodies in the anterior horn cells indicating that morphologic manifestations of both G_M1 and G_M2 gangliosidosis appear early in development.

Author Affiliations
Baltimore

From the departments of neurology (Drs. Percy, McCormick, and Herndon) and pediatrics (Dr. Kaback), Johns Hopkins University School of Medicine, Baltimore. Dr. Kaback is a Joseph P. Kennedy, Jr. Memorial Foundation research scholar in mental retardation. Dr. Percy is now with the Department of Pediatrics, Charles R. Drew Postgraduate Medical School.

Footnotes
Accepted for publication Jan 30, 1973.

Reprint requests to Department of Pediatrics, Charles R. Drew Postgraduate Medical School, 1620 E 119th St, Los Angeles 90059 (Dr. Percy).

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ABSTRACT