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Relation to Clinical Parameters: Exacerbations and Remissions

Jan-Edvin Olsson, MD; Hans Link, MD

Arch Neurol. 1973;28(6):392-399.

Abstract
Increased relative concentrations in cerebrospinal fluid (CSF) of immunoglobulin G (lgG), immunoglobulin A (IgA), the two complement factors β_1c/β_1A globulins and β_1E globulin, and transferrin, were found in CSF specimens obtained during exacerbations of multiple sclerosis (MS), when compared with CSF specimens obtained during remission from the same patients. The absolute concentration of β-trace protein showed a tendency to increase in CSF during exacerbations. No significant differences of the -globulin band pattern were observed on comparison by agarose electrophoresis of CSF specimens from individual patients obtained during exacerbation and remission. Variations of the absolute concentrations of immunoglobulin light chain antigenic determinants of type kappa and lambda during exacerbations and remissions indicate the synthesis within the central nervous system of oligoclonal immunoglobulins with varying light chain type during different phases of the disease.

Author Affiliations
Lund, Sweden

From the Department of Neurology, University Hospital, Lund, Sweden.

Footnotes
Accepted for publication Dec 12, 1972.

Reprint requests to Department of Neurology, University Hospital, S-221 01, Lund, Sweden (Dr. Olsson).

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