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Michael J. G. Harrison, DM, MRCP; David Brownbill, FRACS; Paul D. Lewis, MD, MRCP; R. W. Ross Russell, MD, FRCP

Arch Neurol. 1973;28(6):389-391.

Abstract
The mongolian gerbil has an anomalous circle of Willis, lacking a major posterior communicating artery. Fatal cerebral infarction followed unilateral carotid artery ligation in the neck in 60% of the cases studied. This mortality was reduced by large intraperitoneal injections of dexamethasone. Evidence is presented that this reduction in mortality is associated with a significant reduction in cerebral edema in the infarcted hemisphere.

Author Affiliations
London

From the National Hospital for Nervous Diseases, London.

Footnotes
Accepted for publication Jan 4, 1973.

Reprint requests to the National Hospital for Nervous Diseases, Queen Square, London WC1 N3BG (Dr. Russell).

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