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Treatment With Pyrimidine Nucleosides

Hillel S. Panitch, MD; J. Richard Baringer, MD

Arch Neurol. 1973;28(6):371-375.

Abstract
An experimentally induced herpes simplex virus encephalitis in rabbits was treated with either idoxuridine or cytarabine. The cerebral lesions produced in this model bore histologic and topographic similarities to those seen in humans. Treatment was begun after infection was established in nervous system tissue. In animals treated with idoxuridine there was neither clinical nor histological evidence of a therapeutic effect. Cytarabine initially appeared to inhibit the development of lesions, but the effect was temporary.

Author Affiliations
San Francisco

From the Neurology Research Laboratory, Veterans Administration Hospital, and the Department of Neurology, University of California, San Francisco.

Footnotes
Accepted for publication Jan 30, 1973.

Read before the 23rd annual meeting of the American Academy of Neurology, New York, April 29, 1971.

Reprint requests to Neurology Research Laboratory, Veterans Administration Hospital, 4150 Clement St, San Francisco 94121 (Dr. Baringer).

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