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A Peripheral Mechanism

James N. Campbell; Arthur Taub, MD, PhD

Arch Neurol. 1973;28(5):347-350.

Abstract
Pain and touch thresholds to a needle stimulus were measured on a finger of each of 11 subjects as a function of the presence or absence of continuous, 100-hertz, 1-msec electrical stimulation delivered proximally to the digital nerves of the finger tested at intensities of either 10 to 12 v, 22 v, or 50 v. At 10 to 12 v touch threshold alone was elevated; at 22 v both touch and pain thresholds were elevated; and at 50 v anesthesia and analgesia resulted. The averaged median nerve compound action potential resulting from either periodic bursts or continuous 50-v, 100-Hz, 0.5-msec duration electrical stimulation to the digital nerves of a finger was studied in each of five subjects. An A-delta wave was recorded with periodic bursts of stimuli, but was absent with continuous stimulation. These results indicate that analgesia from electrical stimulation results from peripheral blockade of A-delta fibers.

Author Affiliations
New Haven, Conn

From the Section of Neurosurgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication Dec 12, 1972.

Reprint requests to Section of Neurosurgery, Department of Surgery, Yale University School of Medicine, 789 Howard Ave, New Haven, Conn 06510 (Dr. Taub).

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