 |
|
Brain Uptake of Methylprednisolone AcetateFrom the Cerebrospinal Fluid and Systemic Sites
Gerard M. Lehrer, MD;
Howard S. Maker, MD;
Sulamith Weissbarth, PhD
Arch Neurol. 1973;28(5):324-328.
Abstract
| |
Tritiated- -methylprednisolone-21-acetate was prepared in a dosage form comparable to commercial Depo-Medrol and administered to adult cats either intracisternally or intraperitoneally. Therapeutic amounts of tritiated methylprednisolone acetate were taken up rapidly from the subarachnoid space of cats into the central nervous system to reach levels five to ten times higher than could be attained by systemic injection. Plasma steroid levels were similar whether the drug was placed in the peritoneal or cisternal space. Although the steroid concentration in brain declined rapidly during the first 24 hours after intrathecal injection, steroid was still detectable seven days later. White matter regions tended to attain and retain larger amounts of steroid than gray. Brain steroid levels after intrathecal administration, probably represent a steady state between the rate of diffusion of steroid into the brain from the cerebrospinal fluid (CSF) and its rate of removal by the circulation. Provided that high CSF steroid levels are attained, higher and more prolonged therapeutic brain levels will result after intrathecal administration than by other routes.
Author Affiliations
New York
From the Department of Neurology, Division of Neurochemistry, Mount Sinai School of Medicine of the City University of New York.
Footnotes
Accepted for publication Oct 25, 1972.
Reprint requests to Mount Sinai School of Medicine, Fifth Avenue and 100th Street, New York 10029 (Dr. Lehrer).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Glucocorticoid epidural for sciatica: metabolic and endocrine sequelae
Ward et al.
Rheumatology (Oxford) 2002;41:68-71.
ABSTRACT
| FULL TEXT
|
