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Michael Rasminsky, MD, PhD

Arch Neurol. 1973;28(5):287-292.

Abstract
Increases of temperature of 0.5 C within the physiological range of temperature cause reversible conduction block at identifiable internodes of experimentally demyelinated rat ventral root fibers; such internodes invariably have greatly increased internodal conduction times. At less severely affected internodes, increased temperature causes a reduction in internodal conduction time, as at normal internodes. Such reversible conduction block with increased temperature in demyelinated fibers is suggested as the explanation for the temperature sensitivity of signs and symptoms of patients with multiple sclerosis. It is also suggested that the chronic slowing of conduction that is known to occur in demyelinated nerve fibers is probably of minor clinical significance in human demyelinating disease.

Author Affiliations
London

From the Department of Neurophysiology, Institute of Neurology, Queen Square, London, England.

Footnotes
Accepted for publication Dec 7, 1972.

Reprint requests to Division of Neurology, Montreal General Hospital, 1650 Cedar Ave, Montreal 109 (Dr. Rasminsky).

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