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C. Henry Kempe, MD; Kazuaki Takabayashi, MD; Hiroyuki Miyamoto, MD; Kenneth McIntosh, MD; Wallace W. Tourtellotte, MD; John M. Adams, MD

Arch Neurol. 1973;28(4):278-279.

Abstract
Vaccinia virus neutralizing antibodies were measured in the cerebrospinal fluid (CSF) of 187 patients with multiple sclerosis, 87 patients with other neurologic diseases, and 30 normal controls. Detectable antivaccinia antibody was present in the CSF of 30% of the first group, 3% of the second, and none of the third. These findings may have significance in the search for a causal agent in multiple sclerosis.

Author Affiliations
Denver; Los Angeles

From the Department of Pediatrics, University of Colorado Medical Center, Denver (Drs. Kempe, Takabayashi, Miyamoto, and McIntosh); and the departments of neurology (Dr. Tourtellotte) and pediatrics (Dr. Adams), University of California School of Medicine, Los Angeles.

Footnotes
Accepted for publication Nov 28, 1972.

Read in part before the Society for Pediatric Research, Washington, DC, May 24, 1972.

Reprint requests to Department of Pediatrics, University of Colorado Medical Center, 4200 E Ninth Ave, Denver 80220 (Dr. Kempe).

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