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Normal, Destrophic, and Neurogenic Atrophic Muscle in Mice and Humans

Norio Sakuragawa, MD; Takeshi Sato, MD; Tadao Tsubaki, MD

Arch Neurol. 1973;28(4):247-251.

Abstract
With scanning electron microscopy (SEM), highly organized parallel rows of pairs of openings corresponding to the level of the transverse tubular (T) system were seen on the surface of the muscle from normal mice and humans. The openings, usually round, were always found at the level of the A-I junction and varied from 500 to 1,500 Angstroms in diameter. Disappearance of the T system openings and the A-I banding pattern occurred in focal areas of both dystrophic and neurogenic atrophic fibers in the early stage.

The results from scanning and transmission electron microscopy, and the preparation of specimen—of SEM are discussed.

Author Affiliations
Niigata, Japan

From the Department of Neurology, Brain Research Institute, Niigata (Japan) University. Dr. Sakuragawa is currently with Children's Hospital, Washington, DC.

Footnotes
Accepted for publication Aug 17, 1972.

Read in part before the 13th congress of the Japanese Society of Neurology, Sendai City, Japan, May 14, 1972.

Reprint requests to Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan (Dr. Sakuragawa).

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