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A Possible Mechanism

Irwin A. Brody, MD

Arch Neurol. 1973;28(4):243-246.

Abstract
The monocarboxylic aromatic acids 2,4-dichlorophenoxyacetic acid (2,4-D) and 3-chloro-2, 5, 6-trimethylbenzoic acid, which are myotonia-inducing agents, were found to increase the K -independent p-nitro-phenylphosphatase (basic p-NPPase) activity of microsomes isolated from normal rat skeletal muscle. The activities of K⁺-stimulated p-NPPase and Na⁺,K⁺-stimulated adenosine triphosphatase were unchanged. Similar findings were observed in muscle microsomes from rats made myotonic with 2, 4-D. It is proposed that increased basic p-NPPase activity is related to increased passive flux of K⁺ and that the latter might play a primary role in producing the myotonia.

Author Affiliations
Durham, NC

From the Division of Neurology, Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication Dec 7, 1972.

Reprint requests to Division of Neurology, Duke University Medical Center, Durham, NC 27710 (Dr. Brody).

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