This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Immunological Aspects and Literature Review

David J. Novak, MD; Kenneth P. Johnson, MD

Arch Neurol. 1973;28(4):219-223.

Abstract
Acute idiopathic polyneuritis (Guillain-Barre syndrome) has occasionally been noted during pregnancy and the puerperium. However, relapsing idiopathic polyneuritis is rare in successive pregnancies. We describe a 24-year-old woman with two attacks of disabling polyneuritis in successive pregnancies. She underwent uneventful cesarean sections at full term. Excellent spontaneous recovery followed the first cesarean section over a period of 12 months. Recovery was incomplete ten months after the second delivery. Cerebrospinal fluid was always acellular with mod-$ est elevations of protein. Immunoflu-$ orescent assays for antinerve antibodies of sequential serum and cerebrospinal fluid samples were always negative in this patient, but were positive in five of six patients with acute idiopathic polyneuritis. This difference suggests thát relapsing neuropathy of pregnancy is not immunologic in origin.

Author Affiliations
Cleveland

From the Department of Medicine (Neurology), Case Western Reserve University School of Medicine and Cleveland Metropolitan General Hospital, Cleveland.

Footnotes
Accepted for publication Nov 14, 1972.

Reprint requests to Cleveland Metropolitan General Hospital, 3395 Scranton Rd, Cleveland 44109 (Dr. Johnson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?