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An Index of Muscle Destruction in Man

Salvatore DiMauro, MD; Carolyn Scott; Audrey S. Penn, MD; Lewis P. Rowland, MD

Arch Neurol. 1973;28(3):186-190.

Abstract
Carnitine was identified as a constituent of normal human serum by reaction with a specific enzyme and by thin-layer chromatography. A spectrophotometric enzymatic assay was adapted for use with human serum, based upon the liberation of coenzyme A from acetylcoenzyme A in the presence of carnitine and carnitine acetyltransferase. Normal human serum contains 2.3µmols to 7.0µmols/100ml. Serum content increased to 33.4µmols/100 ml during attacks of myoglobinuria but was not increased in patients with Duchenne dystrophy, liver disease, uremia, or acute myocardial infarction.

Author Affiliations
Philadelphia

From the Spiller Neurological Unit, Hospital of the University of Pennsylvania and the Philadelphia General Hospital, Philadelphia.

Footnotes
Accepted for publication Sept 28, 1972.

Reprint requests to Department of Neurology, 429 Johnson Pavilion, 36th St and Hamilton Walk, Philadelphia 19104 (Dr. DiMauro).

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