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Allan L. Sherwin, MD, PhD; J. Preston Robb, MD; Mortimer Lechter, MD

Arch Neurol. 1973;28(3):178-181.

Abstract
Plasma ethosuximide level was monitored in 70 patients with absence (petit mal) seizures. Levels were linearly related to administered dose. Of 37 ambulatory patients with uncontrolled attacks, 38% (14) had levels below the 95% tolerance limit in contrast to 9% (5) of the controlled group. This difference, due to noncompliance with therapy, was eliminated by regular monitoring. Appropriate adjustment of plasma ethosuximide levels resulted in a reduction of seizures in 48% (18) of previously uncontrolled patients. Practical control of epilepsy increased from 64% (45) to 81% (57). Monitoring of plasma ethosuximide increases the effectiveness of therapy by the recognition of noncompliance and the individualization of drug requirements.

Author Affiliations
Montreal

From the Department of Neurology and Neurosurgery, McGill University, the Montreal Neurological Institute, and the Montreal Children's Hospital, Montreal.

Footnotes
Accepted for publication Sept 14, 1972.

Read in part before the annual meeting of the American Neurological Association, Chicago, June 12, 1972.

Reprint requests to Montreal Neurological Institute, 3801 University St, Montreal 112, Canada (Dr. Sherwin).

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