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Brain Metabolism During HypoglycemiaEffect of Insulin on Regional Central Nervous System Glucose and Energy Reserves in Mice
James A. Ferrendelli, MD;
Ming-Ming Chang, MS
Arch Neurol. 1973;28(3):173-177.
Abstract
Adenosine triphosphate (ATP), phosphocreatine, glucose levels, and metabolic rates were measured in several regions of the central nervous system (CNS) of normal and hypoglycemic (insulin) mice. Following insulin treatment, there was a progressive deterioration of neurological function, a uniform, marked decrease of glucose reserves, and a uniform depression of metabolic rate throughout the CNS; however, ATP and phosphocreatine levels were unaltered. These results indicate that the functional encephalopathy resulting from hypoglycemia is not due to a lack of chemical energy. Also, the present results indicate that the clinically apparent depression of neural function in progressively descending levels of the CNS during hypoglycemia is not a result of a depletion of glucose reserves or depression of metabolic rate more rapidly in the rostral portions of the CNS than in the more caudal portions.
Author Affiliations
St. Louis
From the Edward Mallinckrodt Department of Pharmacology, and the Department of Neurology, Washington University School of Medicine, St. Louis.
Footnotes
Accepted for publication Sept 14, 1972.
Reprint requests to Department of Pharmacology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, Mo 63110 (Dr. Ferrendelli).
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