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Changes in Man

Jes Olesen, MD

Arch Neurol. 1973;28(3):143-149.

Abstract
Using the xenon Xe¹³³ (Xeneisol 133) intracarotid method in man, regional cerebral blood flow (rCBF) was measured in 35 small areas of a hemisphere. it was shown that intracarotid infusion of trimethaphan camsylate (Arfonad) has no effect on rCBF. Marked increases and moderate decreases of perfusion pressure normally cause no measurable change in regional cerebral perfusion pattern nor in absolute flow (rCBF autoregulation). Therefore, autoregulation is impaired when the rCBF changes more than explained by methodologic error. With disease, all degrees of impairment from normal regulation to a completely passive vascular bed may be seen. The derangement may be quantified by the vasoreactivity impairment index (VI): rCBF change, % mean arterial blood pressure change, %. Autoregulation is abnormal in many acute cerebral disorders. The possible diagnostic value of this fact is exemplified and discussed.

Author Affiliations
Copenhagen

From the departments of neurology and clinical physiology, Bispebjerg Hospital, Copenhagen. Dr. Olesen is now with the New York Hospital, Cornell-Medical Center, New York.

Footnotes
Accepted for publication Sept 26, 1972.

Reprint requests to Department of Neurology, New York Hospital, Cornell-Medical Center, 525 E 68th St, New York, NY 10021 (Dr. Olesen).

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