This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

X-Ray Fluorescence Studies

Robert L. Grubb, Jr., MD; Michael E. Phelps, PhD; Michel M. Ter-Pogossian, PhD

Arch Neurol. 1973;28(1):38-44.

Abstract
Absolute regional cerebral blood volume (rCBV) was measured in vivo by the method of stimulated x-ray fluorescence of an iodinated contrast material. This is a noninvasive intravenous technique which allows the study of a volume of the brain approximately 1 cc in size. Initially, the method was validated in dogs and monkeys by demonstrating a good correlation between rCBV values obtained by fluorescence and rCBV values obtained with red blood cells labeled with radioactive chromium (⁵¹ Cr) in frozen, excised brain samples. Absolute regional cerebral blood volume was then measured in normal human volunteers, giving an average value of 3.20 cc/100 gm tissue.

Author Affiliations
St. Louis

From the Division of Neurosurgery, Washington University School of Medicine, and Barnes Hospital, St. Louis (Dr. Grubb); and the Division of Radiation Physics, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis (Drs. Phelps and Ter-Pogossian).

Footnotes
Accepted for publication July 31, 1972.

Reprint requests to Division of Radiation Physics, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis 63110 (Dr. Grubb).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using 11C-Verapamil in the Brain: Studies of Healthy Humans
Muzi et al.
JNM 2009;50:1267-1275.
ABSTRACT | FULL TEXT  

Delayed reduction of tissue water diffusion after myocardial ischemia
Hsu et al.
Am. J. Physiol. Heart Circ. Physiol. 1998;275:H697-H702.
ABSTRACT | FULL TEXT  

Evaluation of the Acetazolamide Test : Vasoreactivity and Cerebral Blood Volume
Okudaira et al.
Stroke 1995;26:1234-1239.
ABSTRACT | FULL TEXT  

Cerebral Blood Volume in Man: Computer Analysis of a Computerized Brain Scan
Penn et al.
JAMA 1975;234:1154-1155.
ABSTRACT