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Brian S. Meldrum, MB, PhD; Roger W. Horton, BSc

Arch Neurol. 1973;28(1):1-9.

Abstract
In adolescent baboons the intravenous injection of bicuculline induced generalized seizures lasting up to five hours, which sometimes led to brain damage or death. Marked initial rises in arterial and cerebral venous pressure were accompanied by severe metabolic and respiratory acidosis, hyperglycemia, and reduced cerebral arteriovenous (AV) differences for oxygen (O₂) and carbon dioxide (CO₂). In the second phase of the seizure (+25 to +300 minutes) blood pressure was normal or low, cerebral AV differences for O_{2 and} CO we_re enhanced, but cerebral venous oxygen tension was not critically reduced. There was severe hyperpyrexia, and hyperkalemia, and sometimes hypoglycemia. Death was cardiovascular in origin. A behavioral and electroencephalographic recovery could occur within three hours of generalized seizure activity lasting one to two hours.

Author Affiliations
Carshalton, Surrey, England

From the Medical Research Council Neuropsychiatry Unit, Carshalton, Surrey, England.

Footnotes
Accepted for publication July 28, 1972.

Preliminary reports have been read before the British Neuropathological Society, Runwell, Essex, July 23, 1971; the Physiological Society, Nottingham, Dec 18, 1971; and the EEG Society, London, Jan 8, 1972.

Reprint requests to MRC Laboratories, Wood-mansterne Rd, Carshalton, Surrey, England (Dr. Meldrum).

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