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Studies in Ageing of the BrainII. Microchemical Analyses of the Nervous System in Alzheimer Patients
Toru Nikaido, MD;
James Austin, MD;
Lucien Trueb, ScD;
Robert Rinehart, PhD
Arch Neurol. 1972;27(6):549-554.
Abstract
Patients with presenile and senile forms of Alzheimer's disease showed increased silicon (Si) in the isolated cores and in the rims of the senile plaques. The increased Si was substantially above background (3 to 50 times). Silicon was not increased as much in patients having Alzheimer changes as part of Down's syndrome. Cortical neurons in Alzheimer's disease showed no increase in Si compared with control neurons. However, Alzheimer neurons with neurofibrillary tangles had more Si than did those neurons without tangles. Silicon was also increased in corpora amylacea of two of three patients with Alzheimer's disease. The increase in Si in neurons with the neurofibrillary change was proportionately greater than that of iron. Indeed, there was no consistent increase in iron in Alzheimer's neurons. The present findings point to a discrete and focal increase in Si. The precise relationship between Si, ageing, and Alzheimer's disease remains to be determined.
Author Affiliations
Denver
From the Division of Neurology, University of Colorado Medical Center, Denver.
Footnotes
Accepted for publication July 10, 1972.
Reprint requests to Division of Neurology, University of Colorado Medical Center, 4200 E Ninth Ave, Denver 80220 (Dr. Austin).
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