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Walid A. Hindo, MD; Raymond A. Clasen, MD; Garimella V. S. Rayudu, PhD; Sylvia Pandolfi

Arch Neurol. 1972;27(6):526-534.

Abstract
The distribution of technetium given as the pertechnetate ion and as the diethylenetriaminepentacetic acid chelate was studied in the brains of dogs with cryogenic lesions. There was more of the chelate than the free form in the necrotic lesion. The radioactivity of the tissue, four hours after injection of the isotope, was compared to the values at 15 minutes. The greatest increase in radioactivity was found in the edema fluid but the concentration of the isotope in both forms was significantly less than that in the serum. The experimental model was then compared to human disease. It was concluded that a scan at four hours should be superior to a 15-minute scan and that a careful comparison of early and late scans could give a quantitative measure of the edema surrounding brain tumors.

Author Affiliations
Chicago

From the departments of radiation therapy (Dr. Hindo), pathology (Dr. Clasen), and nuclear medicine (Dr. Rayudu), Rush-Presbyterian-St. Luke's Medical Center, Chicago.

Footnotes
Accepted for publication June 29, 1972.

Read before the 47th annual meeting of the American Association of Neuropathologists, San Juan, PR, June 27, 1971.

Reprint requests to 1753 W Congress Parkway, Chicago 60612 (Dr. Clasen).

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