This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (30)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Jerry R. Mendell, MD; Dennis L. Murphy, MD; W. King Engel, MD; Thomas N. Chase, MD; Edna Gordon, MS

Arch Neurol. 1972;27(6):518-520.

Abstract
Several studies have raised the question of abnormal biogenic amine metabolism in Duchenne muscular dystrophy (DMD). A small group of DMD patients and controls were screened for abnormalities in systemic biogenic amine metabolism in a carefully controlled clinical environment The mean 24-hour urinary excretion levels of norepinephrine, epinephrine, and 5-hydroxyindoleacetic acid (5-HIAA) were identical in the group of DMD patients compared to their normal sibling controls. In the cerebrospinal fluid (CSF), 5-HIAA and homovanillic acid (HVA) levels were similar in DMD patients and controls, and no 5-hydroxytryptamine (5-HT) was detected in the CSF of either group. This study suggests that the characteristic lesions of DMD do not result from a simple excess of circulating amines.

Author Affiliations
Bethesda, Md

From the Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, and the Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Md.

Footnotes
Accepted for publication June 28, 1972.

Reprint requests to Medical Neurology Branch, National Institutes of Health, Bethesda, Md 20014 (Dr. Mendell).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Muscular Dystrophies and Related Disorders: I. The Muscular Dystrophies
Furukawa and Peter
JAMA 1978;239:1537-1542.
ABSTRACT  

Biochemical Abnormalities of Erythrocyte Membranes in Duchenne Dystrophy: Adenosine Triphosphatase and Adenyl Cyclase
Mawatari et al.
Arch Neurol 1976;33:489-493.
ABSTRACT  

Pathogenesis of Muscular Dystrophies
Rowland
Arch Neurol 1976;33:315-321.
ABSTRACT  

Serotonin-Induced Muscle Weakness
Patten et al.
Arch Neurol 1974;31:347-349.
ABSTRACT  

Serotonin and Platelet Function in Duchenne Muscular Dystrophy
Murphy et al.
Arch Neurol 1973;28:239-242.
ABSTRACT