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John B. Selhorst, MD; Benjamin Kaufman, MD; Samuel J. Horwitz, MD

Arch Neurol. 1972;27(5):453-455.

Abstract
Two patients received large amounts of diphenylhydantoin for 28 months or more. While receiving diphenylhydantoin, they acquired severe cerebellar deficits and a peripheral neuropathy that was irreversible. In each case, marked cerebellar atrophy was demonstrated by pneumoencephalography. The cerebellar atrophy and irreversible dysfunction in these two cases is attributed to long-term, high dosages of diphenylhydantoin.

Author Affiliations
Cleveland

From the departments of medicine, pediatrics, and radiology, and the Division of Neurology, Case Western Reserve University School of Medicine, and University Hospital, Cleveland.

Footnotes
Accepted for publication July 10, 1972.

Reprint requests to Division of Neurology, University Hospitals, 2065 Adelbert Rd, Cleveland 44106 (Dr. Horwitz).

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