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Regional Cerebral Blood FlowResponse to Carbon Dioxide Inhalation in Cerebrovascular Disease
Lawrence C. McHenry, Jr., MD;
Herbert Goldberg I., MD;
Marvin E. Jaffe, MD;
Edgar J. Kenton III., MD;
James W. West, PhD;
Edward S. Cooper, MD
Arch Neurol. 1972;27(5):403-412.
Abstract
Regional cerebral blood flow (rCBF) measurements were performed in three groups of patients before and during 5% carbon dioxide inhalation. In the first group with normal cerebral angiograms, the rCBF increased 60%. Patients with diffuse cerebrovascular disease had baseline flow of 34 ml/100 gm/min with an increase to 44 ml/100 gm/min during hypercapnia. In 20 patients with angiographic evidence of focal vascular disease, blood flow was measured both as the hemispheric mean cerebral blood flow (CBF) and as rCBF in normal or nonfocal regions and in abnormal or focal regions. In nonfocal regions, mean rCBF increased from 37 to 50 ml/100 gm/min; in focal regions, rCBF increased from 28 to 36 ml/100 gm/min. Fifty-seven percent of the focal regions and 71% of the nonfocal regions increased significantly during hypercapnia.
Author Affiliations
Philadelphia
From the Stroke Research Center and the Neurology and Medical Services, Philadelphia General Hospital; the Department of Neurology, Jefferson Medical College; and the departments of neurology, medicine, and pharmacology, University of Pennsylvania, Philadelphia.
Footnotes
Accepted for publication March 22, 1972.
Read by title at the 96th annual meeting of the American Neurological Association, Washington, DC, June 14-16, 1971, and presented at the International Symposium on Cerebral Blood Flow, Rome, Oct 29, 1971.
Reprint requests to Stroke Research Center, Philadelphia General Hospital, Philadelphia 19104 (Dr. McHenry).
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