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A Central Nervous System Disease Caused by a Slow Virus

Amin A. Faris, MD; A. Julio Martinez, MD

Arch Neurol. 1972;27(4):357-360.

Abstract
In case of primary progressive multifocal leukoencephalopathy, light microscopy demonstrated amphophilic intranuclear inclusion bodies, and electron microscopy confirmed the presence of papova-like and myxovirus in glial cells. The hypothesis is offered that the disease is caused by a slow virus, not necessarily having an altered immune mechanism as a prerequisite for its propagation, and that altered immunity may provide a more favorable background for its proliferation.

Author Affiliations
Memphis

From the Department of Pathology, Baptist Memorial Hospital, and the departments of pathology and neurology, University of Tennessee College of Medicine, Memphis.

Footnotes
Accepted for publication May 18, 1972.

Reprint requests to Institute of Pathology, 858 Madison Ave, Memphis 38103 (Dr. Martinez).

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