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Indifference to PainA Chronic Peripheral Neuropathy With Mosaic Schwann Cells
Otto Appenzeller, MD, PhD;
Mario Kornfeld, MD
Arch Neurol. 1972;27(4):322-339.
Abstract
The clinical features, laboratory investigations, and tests of autonomic function in two sisters with indifference to pain are reported. The disorder differs from other syndromes associated with indifference to pain. The morphologic, quantitative, histologic, teased-fiber preparations, and electron microscopic features of the sural nerves showed a chronic neuropathy, a feature of which was the presence of "mosaic" Schwann cells. The clinicopathological correlation was not satisfactory; nevertheless, peripheral nerve disease was found in this variety of indifference to pain.
Author Affiliations
Albuquerque, NM
From the departments of neurology, medicine, and pathology, University of New Mexico School of Medicine, Albuquerque, NM.
Footnotes
Accepted for publication May 26, 1972.
Reprint requests to Department of Neurology, University of New Mexico School of Medicine, 2211 Lomas Blvd NE, Albuquerque, NM 87106 (Dr. Appenzeller).
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