This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Masaharu Takamori, MD

Arch Neurol. 1972;27(4):285-291.

Abstract
Investigations were performed in four patients with a myasthenic syndrome in which fractional release of the immediately releasable acetylcholine at nerve terminals is defective (3 of them were typical of Eaton-Lambert syndrome), 35 patients with classical myasthenia and 20 normal subjects. In the four patients with myasthenicsyndrome, administration of caffeine produced an increase in amplitude of muscle action potentials evoked with single and repetitive nerve stimulation, and also provided a reduction of abnormally marked facilitation of muscle action potentials evoked shortly after single nerve stimuus and brief tetanic nerve stimuli. These effects of caffeine on neuroyal transmission were similar to those obtained after administration of calcium. Caffeine thus was found to have the same therapeutic effect as calcium on a myasthenic syndrome with fractional acetylcholine release defect. Both drugs provided no significant change in the conditions of classical myasthenics and normals.

Author Affiliations
Nagasaki, Japan

From the First Department of Internal Medicine, Nagasaki (Japan) University School of Medicine, and the Department of Neurology, West Virginia University Medical Center, Morgantown, WVa.

Footnotes
Accepted for publication March 30, 1972.

Reprint requests to First Department of Internal Medicine, Nagasaki University School of Medicine, 7-1, Sakamoto-cho, Nagasaki, Japan (Dr. Takamori).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Eaton-Lambert (Myasthenic) Syndrome in Association With Systemic Lupus Erythematosus
Hughes and Katirji
Arch Neurol 1986;43:1186-1187.
ABSTRACT  

Malignant Thymoma With Dysautonomia and Disordered Neuromuscular Transmission
Tabbaa et al.
Arch Neurol 1986;43:955-957.
ABSTRACT  

Eaton-Lambert Syndrome in a 9-Year-Old Girl
Chelmicka-Schorr et al.
Arch Neurol 1979;36:572-574.
ABSTRACT  

The Eaton-Lambert Syndrome in Ocular Myasthenia Gravis
Oh
Arch Neurol 1974;31:183-186.
ABSTRACT  

The Role of Cyclic 3', 5'-Adenosine Monophosphate in Neuromuscular Transmission
Takamori et al.
Arch Neurol 1973;29:420-424.
ABSTRACT