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Thomas Mathews, MD; John Moossy, MD

Arch Neurol. 1972;27(3):263-268.

Abstract
A 44-year-old man with an 18-year history of multiple sclerosis developed signs and symptoms of a cerebral neoplasm three years before his death. The central nervous system showed the demyelinated plaques of multiple sclerosis plus a mixed glioma (oligodendroglioma-astrocytoma) in the left parietal and frontal lobes. An additional feature was the coexistence of Charcot-Marie-Tooth disease, a combination of diseases not previously reported. We found eleven additional verified cases with this uncommon association between glioma and multiple sclerosis. From the data no evidence could be found that the gliomas developed from neoplastic transformation of reactive astrocytes in multiple sclerosis plaques. The coexistence of the two diseases in the same patient is probably fortuitous.

Author Affiliations
Winston-Salem, NC

From the Department of Pathology (Neuropathology), Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.

Footnotes
Accepted for publication April 10, 1972.

Reprint requests to Department of Pathology (Neuropathology), University of Pittsburgh School of Medicine, Pittsburgh 15213 (Dr. Moossy).

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