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Ineffectiveness in Experimental Cerebral Microembolism

Barry A. Siegel, MD; Rebecca K. Studer, MS; E. James Potchen, MD

Arch Neurol. 1972;27(3):209-212.

Abstract
Ischemic brain injury was produced in rats by the intracarotid injection of microspheres. During a 72-hour period of study, large doses of dexamethasone did not favorably affect survival, severity of brain edema, brain electrolyte shifts, or alterations in cerebral red blood cell, albumin, and pertechnetate spaces. The role of steroid therapy in cerebral infarction requires critical clinical appraisal.

Author Affiliations
St. Louis

From the Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis.

Footnotes
Reprint requests to 510 S. Kingshighway Blvd, St Louis 63110 (Dr. Siegel).

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ABSTRACT