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Relative Efficacy in a Double-Blind Study

Bernard Cohen, MD; J. M. B. Vianney deJong, MD

Arch Neurol. 1972;27(2):129-135.

Abstract
In a double-blind crossover study, meclizine hydrochloride was shown to be significantly more effective than placebo in treating patients with positional and continuous vertigo of vestibular origin. Meclizine reduced the severity and frequency of attacks, as well as signs and symptoms associated with the vertigo. These included nausea, positional and positioning nystagmus, and postural instability. There was no difference in the response of patients with disease of the peripheral or central vestibular system.

Author Affiliations
New York

From the Department of Neurology, Mount Sinai School of Medicine, New York.

Footnotes
Accepted for publication March 29, 1972.

Reprint requests to Atran 710, Mcunt Sinai School of Medicine, 1 E 100th St, New York 10029 (Dr. Cohen).

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