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Amyotrophic Lateral SclerosisAssociation With Schizophrenic Symptoms and Showing Alzheimer's Tangles
Yoshiro Yase, MD;
Nobuteru Matsumoto, MD;
Kazushige Azuma, MD;
Yoshimasa Nakai, MD;
Hirotsugu Shiraki, MD
Arch Neurol. 1972;27(2):118-128.
Abstract
A 32-year-old Japanese patient with amyotrophic lateral sclerosis (ALS) had schizophrenic symptoms antedating the neurological picture. Neuropathologically, there was a wide distribution of Alzheimer's neurofibrillary change, mainly in the cerebral cortex but less in the basal ganglia, in addition to the classical changes of ALS. This patient came from one of the foci of ALS located in the Kii Peninsula of Japan. The similarities to Alzheimer's disease and to the ALS-parkinsonism-dementia complex cases on Guam is of striking interest.
Author Affiliations
Wakayama City, Japan; Tokyo
From the Division of Neurological Diseases (Drs. Yase, Matsumoto, and Azuma) and the Department of Pathology (Dr. Nakai), Wakayama Medical College, Wakayama City, Japan, and the Department of Neuropathology, Institute of Brain Research, Tokyo University Medical School (Dr. Shiraki), Tokyo.
Footnotes
Accepted for publication Dec 15, 1971.
Reprint requests to Division of Neurological Diseases, Wakayama Medical College, Wakayama City, Japan 640 (Dr. Yase).
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