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Elizabeth C. Dooling, MD; John F. Barlow, MD; Sioux Falls, SD; Jerome V. Murphy, MD; Edward P. Richardson, Jr., MD

Arch Neurol. 1972;27(1):79-84.

Abstract
A 6-year-old girl had a large cyst of the cavum septi pellucidi associated with other anomalies of neural tube development, including a lumbosacral meningomyelocele, aqueductal stenosis, and a partial defect of the splenium of the corpus callosum. Hydrocephalus was the main clinical problem; ventriculoatrial shunting provided relief, to the extent that intellectual development was satisfactory The anatomical evidence suggests pathogenetic methanisms both early and late in intrauterine life, with an intervening period of normal development. Although the mother was exposed to several viruses during pregnancy, the significance of this is uncertain, and the cause of the developmental abnormalities remains unknown.

Author Affiliations
Boston; Boston

From the Charles S. Kubik Laboratory for Neuropathology of the James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the departments of neurology-neuropathology and pathology, Harvard Medical School, Boston (Drs. Dooling; Murphy; and Richardson); and the Department of Pathology, Sioux Valley Hospital, Sioux Falls, SD (Dr. Barlow). Dr. Murphy is now with the University of Pittsburgh Medical School, Pittsburgh.

Footnotes
Accepted for publication Jan 12, 1972.

Reprint requests to Neuropathology Laboratory, Massachusetts General Hospital, Boston 02114 (Dr. Dooling).

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