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Benjamin O. Osuntokun, PhD, MD, MRCP(L); Olajide Bademosi, MB, BS, MRCP(UK); Kayode Ogunremi, MB, BS; Stephen G. Wright, MB, BS

Arch Neurol. 1972;27(1):7-13.

Abstract
The neurospsychiatric manifestations of typhoid fever in 959 Nigerian patients included confusional states or delirium (57%), semicoma (2.6%), coma (1.0%), meningism (5%), meningitis (0.2%), convulsions (1.7%), generalized myoclonus (0.5%), focal neurological deficit— deafness, hemiplegia, infranuclear facial palsy— (0.5%), transient or evanescent parkinsonism (1.0%), symmetrical, usually transient, spasticity of all limbs (3.1%), and generalized hypotonicity (0.2%). Seven patients had symmetrical sensorimotor polyneuropathy without cytoalbuminological dissociation in cerebrospinal fluid, and three patients had a mononeuritis. One young man developed motor neuron disease two months after recovering from typhoid fever. In five patients (0.5%), the initial diagnosis was schizophrenia. Two developed schizophrenic psychoses, and two other patients suffered from temporary amnesia during convalescence.

Author Affiliations
Ibadan, Nigeria

From the departments of medicine, psychiatry, and neurology, University College Hospital, Ibadan, Nigeria.

Footnotes
Accepted for publication Dec 15, 1971.

Reprint requests to Neurology Unit, University College Hospital, Ibadan, Nigeria.

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