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Kevin E. Bove, MD; Samuel A. Shelburne, Jr., MD

Arch Neurol. 1972;27(1):42-44.

Abstract
Intranuclear inclusions suggesting intranuclear virus replication were found in sarcolemmal nuclei of the diaphragm and intercostal muscles of a patient with subacute encephalitis with Cowdry type A intranuclear inclusion bodies. Muscle fibers exhibited severe degenerative changes, including occasional stigmata of denervation. The morphological evidence favors interpretation of both the encephalitis and the myopathy as virus induced. This case provides support for the emerging concept of viral myopathy. Although myopathy in patients with latent encephalitis due to measles virus has not been stressed, the frequency of its occurrence has not been examined by systematic postmortem sampling of the voluntary musculature.

Author Affiliations
Cincinnati

From the University of Cincinnati College of Medicine, and the Children's Hospital Research Foundation, Cincinnati.

Footnotes
Accepted for publication Jan 31, 1972.

Reprint requests to Children's Hospital Medical Center, the Children's Hospital Research Foundation, Elland and Bethesda avenues, Cincinnati 45229 (Dr. Bove).

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ABSTRACT