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Richard D. Travers, MD; Edward H. Reynolds, MD; Brian B. Gallagher, MD, PhD

Arch Neurol. 1972;27(1):29-33.

Abstract
In 118 adult epileptic patients with grand mal and/or temporal-limbic epilepsy, the mean serum concentration of diphenylhydantoin, phenobarbital, primidone, and phenobarbital derived from primidone increased directly with mean dose administered. With a given dose of each drug, wide individual variation in serum concentration existed. Women consistently received a larger dose of each medication per unit of body weight than men, yet women uniformly obtained lower serum concentrations of each drug. Those subjects with more frequent and/or more poorly controlled seizures received the largest doses of diphenylhydantoin and phenobarbital and obtained higher serum concentrations of these drugs than those patients with less frequent and better controlled seizures. Men and women were unevenly distributed with regard to seizure frequency and control. The heterogenous nature of a population of seizure patients was emphasized.

Author Affiliations
New Haven, Conn

From the Department of Neurology, Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication Jan 27, 1972.

Read before the annual meeting of the American Neurological Association, Washington, DC, April 28, 1971.

Reprint requests to Department of Neurology, Yale University School of Medicine, 333 Cedar St, New Haven, Conn 06510 (Dr. Gallagher).

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