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Harry H. White, MD; John H. Kepes, MD; Charles H. Kirkpatrick, MD; R. Neil Schimke, MD

Arch Neurol. 1972;26(4):359-365.

Abstract
The clinical and pathological data of a patient with congenital hypogammaglobulinemia who developed a subacute panencephalitis are presented. The inability of the patient to produce circulating (humoral) antibodies renders unlikely an antibodymediated pathogenesis of the encephalitis. A review of the available data suggests that patients with subacute encephalitis may have a partial rather than generalized deficiency in the immune response. Such a partial deficiency may allow for persistence of the virus for prolonged periods of time. Any alteration in host-virus relationship might result in uncontrolled viral replication and the appearance of a modified form of disease, such as subacute encephalitis. Since subacute encephalitis may occur in patients with normal as well as with deficient humoral immunity, it is probable that cellular immune factors are of greater importance in resistance to slow virus infections.

Author Affiliations
Kansas City, Kan

From the departments of medicine (Drs. White and Kirkpatrick), pathology (Dr. Kepes), and pediatrics (Dr. Schimke), University Hospital, University of Kansas School of Medicine, Kansas City, Kan.

Footnotes
Accepted for publication Dec 13, 1971.

Reprint requests to University of Kansas Medical Center, 39th and Rainbow, Kansas City, Kan 66103 (Dr. Schimke).

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