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Electrophysiological Study of Neuromuscular Transmission and Muscle Contraction in Two Patients

Masaharu Takamori, MD; Ludwig Gutmann, MD; Thomas W. Crosby, MD; James D. Martin, MD

Arch Neurol. 1972;26(4):326-335.

Abstract
Two hypothyroid patients, one with autoimmune thyroiditis and pernicious anemia and the other with idiopathic primary myxedema, were studied electrophysiologically. The former showed findings of the Eaton-Lambert myasthenic syndrome, and the latter showed findings of the desensitization block of neuromuscular transmission or the conduction block at the fine terminal filaments of the motor axon. The muscle contraction study revealed the posttetanic muscle contracture without electrical discharges in the former, and the posttetanic twitch depression and the decreased tetanic force in the latter.

Author Affiliations
Morgantown, WVa

From the Department of Neurology, West Virginia University Medical Center, Morgantown, WVa. Dr. Takamori is now with the First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.

Footnotes
Accepted for publication Aug 3, 1971.

Reprint requests to the Department of Neurology, West Virginia University Medical Center, Morgantown, WVa 26506.

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