This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Phillip D. Swanson, MD

Arch Neurol. 1972;26(2):169-174.

Abstract
Thin slices prepared from guinea pig cerebral cortex were incubated in the presence of varying concentrations of penicillin G sodium. Early effects included a fall in levels of creatine phosphate and adenosine triphosphate. Lactate production and respiration were inhibited. Slices lost potassium ions from the noninulin space, but this effect occurred more slowly than the effects on high-energy phosphates. Penicillin appears to interfere primarily with energy production in cerebral tissues. Its epileptogenic properties could, however, result from leakage of potassium ions from some elements with secondary effects on others.

Author Affiliations
Seattle

From the Division of Neurology, Department of Medicine, University of Washington School of Medicine, Seattle.

Footnotes
Accepted for publication July 27, 1971.

Reprint requests to Division of Neurology, Department of Medicine, University of Washington School of Medicine, Seattle 98105 (Dr. Swanson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Penicillin-Induced Segmental Myoclonus: I. Motor Responses and Intracellular Recording From Motoneurons
Kao and Crill
Arch Neurol 1972;26:156-161.
ABSTRACT  

Penicillin-Induced Segmental Myoclonus: II. Membrane Properties of Cat Spinal Motoneurons
Kao and Crill
Arch Neurol 1972;26:162-168.
ABSTRACT