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Changes in Cerebrospinal Fluid Dynamics as a Function of Time

Gerald M. Hochwald, MD; Warren E. Lux, Jr., MD; Abraham Sahar, MD; Joseph Ransohoff, MD

Arch Neurol. 1972;26(2):120-129.

Abstract
Cerebrospinal fluid (CSF) turnover was studied in cats by ventricular perfusion at various time intervals after the intracisternal injection of 175 to 200 mg of kaolin. At seven days, CSF absorptive capacity was minimal and intraventricular pressure was high. During this time interval, the occurrence of quadriplegia in some animals was attributed to microscopic changes observed in kaolin meningitis and also to the elevated intraventricular pressure. After three weeks, when transventricular absorption occurred, CSF absorptive capacity increased, and intraventricular pressure returned to normal. The development of transventricular absorption was accompanied by an increase in water content of periventricular white matter. Results from perfusion studies at a constant perfusion pressure demonstrated that CSF production rates were similar in both acute and chronic hydrocephalic cats. However, CSF production was affected by changes in perfusion pressure.

Author Affiliations
New York

From the departments of neurology (Drs. Hochwald and Lux) and neurosurgery (Drs. Sahar and Ransohoff), New York University Medical Center, New York. Dr. Sahar is now with the Department of Neurosurgery, Hebrew University, Hadassah Medical School, Jerusalem, Israel.

Footnotes
Accepted for publication July 7, 1971.

Reprint requests to Department of Neurology, New York University Medical Center, 550 First Ave, New York 10016 (Dr. Hochwald).

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