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The Role of Prefrontal Cortex in Grand Mal Convulsion
Sidney Goldring, MD
Arch Neurol. 1972;26(2):109-119.
Abstract
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In five patients with intractable generalized seizures and nonfocal electroencephalograms, direct brain recordings (from prefrontal and parietal cortices, mesial temporal lobe, and mesial thalamus) were made at rest, during spontaneously occurring seizure, and during pentylenetetrazol induced grand mal convulsion. There was a limited correlation between EEG and records made directly from the brain; generalized atypical spike and wave activity which characterized the interictal EEG emanated from frontal lobes. Mesial thalamus did not show the atypical spike and wave activity seen in pre-frontal cortex; nor could such focal cortical discharge or convulsion be produced by stimulation of mesial thalamus. Both spontaneous and pentylenetetrazol induced grand mal convulsion originated in prefrontal cortex, the thalamus became involved secondarily. The findings together with those extant in current literature indicate an important role for prefrontal cortex in the genesis of both idiopathic and acquired grand mal convulsion.
Author Affiliations
St. Louis
From the Division of Neurological Surgery, Washington University School of Medicine, St. Louis.
Footnotes
Accepted for publication July 15, 1971.
Read in part before the 51st annual meeting of the Society of Neurological Surgeons, Phoenix, Ariz, Feb 17, 1971.
Reprint requests to Division of Neurological Surgery, Washington University School of Medicine, Barnes Hospital Plaza, St. Louis 63110 (Dr. Goldring).
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